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KMID : 0043320140370060706
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Archives of Pharmacal Research
2014 Volume.37 No. 6 p.706 ~ p.712
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Inhibition of NF-κB transcriptional activation in HepG2 cells by diterpenoids from the soft coral Sinularia maxima
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Thao Nguyen Phuong
Nam Nguyen Hoai
Cuong Nguyen Xuan
Luyen Bui Thi Thuy
Tai Bui Huu
Kim Ji-Eun
Song Seok-Bean
Kiem Phan Van
Minh Chau Van
Kim Young-Ho
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Abstract
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Anti-inflammatory transcriptional effects of nineteen compounds (1?19) from the soft coral Sinularia maxima were evaluated using NF-κB luciferase and reverse transcriptase polymerase chain reaction. Compounds 1, 2, 4, 8, 15, 17, and 18 significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells in a dose-dependent manner, with IC50 values ranging from 15.81 ± 2.29 to 29.10 ± 1.54 μM. Furthermore, the transcriptional inhibitory function of these compounds was confirmed by a decrease in intercellular adhesion molecule-1 and inducible nitric oxide synthase gene expression levels in HepG2 cells. These results provide a scientific rationale for the use of the soft coral S. maxima warrant further studies to develop new agents for the prevention and treatment of inflammatory.
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KEYWORD
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Soft coral, Sinularia maxima, Nuclear factor-κB, HepG2 cell, ICAM-1, iNOS
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